Over the years, the disease diabetes has evoked landmark findings which have facilitated its management. Yet till now, medical science knows only in part about this. Despite the many hypoglycemic agents so far in use, there are reports of high profile side-effects and increased inefficacy after initial response. Continued reliance on such conventional therapies is hence gloomy. Phytotherapy shows comparative advantage, as botanicals having diverse secondary metabolites, can exert multiple interventions at various stages of the disease, and besides, bear reduced economic burden. This underscores the global ?herbal renaissance? on diabetes therapy. Rigorous investigations to confirm its excellence over the existing therapies is thus necessary. Very few time-tested researches have been carried out in this regards. This research-based monograph on synergistic action of bitter leaf and neem used traditionally in Africa and Asia respectively, fills the gap. The synthesis of skills from Biochemistry, Physiology, Anatomy, Medicine, Botany, and Pharmacology is demonstrated. Students, teachers, researchers and professionals in these fields would find the work a master-piece.