This work was conducted to evaluate the beneficial effect of grain presoaking in kinetin (0.1 mM), spermine (0.3 mM) or their interaction on wheat plants (Triticum aestivum L. variety Sakha 93) irrigated with seawater. It is clear from this investigation that irrigation of wheat plants with 25% seawater had negative effects on growth, metabolism and productivity of wheat plants. On the other hand, grain presoaking in kinetin, Spm or their interaction displayed a positive role in improving the ability of the wheat cultivar (Sakha 93) to become more salt-tolerant. On the basis of the results obtained, we concluded that when it is necessary to use seawater for irrigation of wheat plants cultivar Sakha 93, grain presoaking in kinetin, Spm or their interaction is advisable to obtain plant growth and yield very close to, or even exceeding, that obtained under normal conditions. It is of particular interest to mention that kinetin was more effective than Spm. Furthermore, the treatment with kinetin + Spm was the most effective.