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Synthesis and QSAR Study of Benzimidazole Derivatives


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

Life threatening infections caused by pathogenic fungi are becoming increasingly common, especially in individuals with suppressed immune systems. However, there are only a limited number of antifungal drugs available for such infections, which leads to a strong need to develop new classes of compounds having antifungal activity. From the literature survey; it was found that there has been a lot of research going in the field of novel antifungal drug development. It was found that many antifungal agents contain benzimidazole moiety in their structure. Therefore benzimidazole was selected for the development of new chemical entities as potential antifungal agents. Fifteen derivatives of benzimidazole were synthesized using different substituted phenol as a side chain. Synthesized compounds were characterized by chromatographic methods, Infrared spectroscopy and Nuclear Magnetic Resonance spectroscopy for their structural confirmation. These compounds were tested for antifungal activity. Furthermore, these benzimidazole derivatives were subjected to QSAR study. These compounds provide a preliminary insights into newer antifungal agents and which can help further modification.

Product Specifications
SKU :COC31037
AuthorGayatri Suryawanshi,Rajendra Doijad and Vitthal Kulkarni
Number of Pages188
Publishing Year5/26/2012
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00