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Synthesis and Screening of Anti-Hypertension Drug Candidates

 

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  • Product Description
 

The ability to transfer the stereochemical information, contained within a dicobalt hexacarbonyl complexed chiral non-racemic propargyl alcohol into the resulting product still remains a challenge to the synthetic chemist. Benzopyran derivatives have a wide range of biological activity; developing a practical synthetic route to their synthesis has a huge importance in the development of new therapeutic drugs. When it comes to therapeutic drugs, their stereoselective synthesis is crucial because one of the isomers is often not only ineffective but may also be toxic. This book investigates asymmetric synthesis of chiral non-racemic propargyl alcohols and the synthesis of biologically active novel benzopyran derivatives using the Nicholas reaction. The biological testing of the newly synthesized compound revealed that they are potent anti-hypertension drug candidates. From the biological screening, the newly synthesized benzopyrans are not only active and relaxed smooth muscle but also seem to have different mode of action from that of cromakalim, the well known potassium channel opener. Hence, this book is very useful for research chemists working on drug discovery and academician.

Product Specifications
SKU :COC98407
AuthorKibur Hunie Tesfa
LanguageEnglish
BindingPaperback
Number of Pages336
Publishing Year2011-08-10T00:00:00.000
ISBN978-3639373059
Edition1 st
Book TypeOrganic chemistry
Country of ManufactureIndia
Product BrandNot defined
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-18 00:00:00
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