The aim of this work is to prepare a series of mixed ligand complexes of Pd(II) and Cu(II) based on the cyclic dithiarine derivatives using different nitrogen , phosphorous and arsine containing ligands, and to study structure and bonding aspects of these new different complexes , using the suitable techniques.The chosen metal ions and the ligands are both scientific and pharmaceutical importance. The work is to be accomplished through the following steps: 1.Preparation of dithiarine ligand starting from dithiooxamide. 2.Preparation of Pd(DMSO)2Cl2 as astarting material. 3.Preparation of dithiarine complex of Pd(II) by reaction with Pd(DMSO)2Cl2. 4.Reaction of dithiarine complex of Pd(II) with the following ligands, NPh3 , PPh3, AsPh3, 2,2/-dipyridyl and dithiooxamide. 5.Preparation of analoguses complexes of Cu(II) as described above starting with copper chloride. 6.Characteriztion of all the prepared compounds using infrared, ultra violet-visible Spectroscopy, magnetic susceptibility and conductivity measurements and metal analysis. 7.Test the biological activity of all compound aginst two bacteria Staphylococcus aureus and Pseudomonas mallei.