Synthesis of Curcumin Analogues as Novel Anti Malarial Agents


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

A series of dibenzylidencyclohexanone were synthesized by clasein-schmidt condensation reaction and twelve of them were evaluated in vitro for blood stage antiplasmodial properties in Plasmodium falciparum culture using SYBR- green-I fluorescence assay. The structures of newly synthesized compounds were ascertained on the basis of their analytical and spectral profiles. The compound (2E,6E)-2,6-bis(3-nitrobenylidene) cyclohexanones (11) was found to be most active with IC50 of 66 mg/ml against chloroquine sensitive (3d7)strain.Our results revealed that some of these exhibited promising antiplasmodial activities which can be further explored as potential leads for the development of cheaper, safe, effective and potent drugs against chloroquine-resistant malarial parasites.

Product Specifications
SKU :COC85108
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
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