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Synthesis of Heterocyclic Compounds with expected Bioligical Activity

 

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This work has been carried out to investigate the chemical reactivity and synthetic potentiality of 2-thioxohydropyridine 11a-d via their reaction with several active halogencontaining compounds to afford the corresponding 2-alkylthiopyridine in some cases and thieno[2,3-b]pyridine directly in most cases. Thieno[2,3-b]pyridine-2-carbohydrazides obtained through the reaction of 2-ethoxycarbonylthienopyridines with hydrazine hydrate which in turn, used to obtain the corresponding pyrimidinones 20-26(a-d), 1,3,4- oxdiazoles 28, 30(a-d), pyrazolothienopyridine derivatives (32a-d) thienopyridine-3- amines (34a-d), pyrazolones (36a-d), pyrazolidine-3,5-diones (38a-d). 3- Aminopyrazolopyridine obtained via the reaction of 11a-e or 49a-e with hydrazine hydrate which in turn, reacted with nitrous acid to give the diazonium salts 51a-e which coupled with several active-hydrogen containing reagents to give the corresponding triazines. The structures of all newly synthesized heterocyclic compounds were elucidated by considering the data of IR, 1H NMR (?ppm), mass spectra as well as that of elemental analyses. Anti-Alzheimer, anti COX-2 and anti-Cancer activities were investigated for all newly

Product Specifications
SKU :COC95171
AuthorLabeeb Mohamed Shaif
LanguageEnglish
BindingPaperback
Number of Pages300
Publishing Year2011-12-08T00:00:00.000
ISBN978-3847311881
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-14 00:00:00
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