In recent decades, the tremendous biological potential of the highly substituted pyrazole scaffolds have attracted many chemists to synthesize this class of molecules. The classical methods to synthesized pyrazoles and involves the condensation of diketone compound or its synthetic equivalent with hydrazine in appropriate organic solvent. On the other hand, functionalized ketene dithioacetals are versatile intermediates in organic synthesis for the construction of substituted heterocycles such as pyrazoles. Thus, the practical synthesis of poly substituted pyrazole based small molecules is of great importance. The present research has demonstrated the synthesis of highly functionalized Pyrazoles using ketene dithioacetal and followed by N-alkylation using TBAB and water as solvent in excellent yield and its biological study.
|Author||Mahesh Savant,Vipul Audichya and Yogesh Naliapara|
|Number of Pages||68|
|Country of Manufacture||India|
|Product Brand||Scholars' Press|
|Product Packaging Info||Box|
|In The Box||1 Piece|
|Product First Available On ClickOnCare.com||2015-06-08 00:00:00|