Over a period of last decades research has become more important due to its usefulness to our society especially in the field of medicinal chemistry. Nowadays due to booming development in the paper and digital publication, it is important to publish authentic research work on appropriate medium. So I would like to present my efforts in research by publishing it in my book. This book contain synthesis of schiff base of pyrazole aldehyde and pyrimidine derivatives. This book is useful to research students of organic chemistry.