This book provides information about anthracene and synthetic methods of anthracene derivatives with antimicrobial activities. The Anthracene derivatives are drugs of therapeutic importance having wide range of antibacterial activity. Some simple anthracene derivatives have been reported to exhibit bactericides, insecticides,germicides, antipsychotic,antiemetic and disinfectant activity. So the problem on the synthesis of some new anthracene derivatives is under taken for project. The synthesis of anthracene derivatives involves the reaction such as Nucleophilic displacement, catalytic cyclisation, cycloaddition, Diel – Alder reaction etc. The structure of the synthesized compounds is confirmed by IR, NMR Spectral data and elemental analysis. Further these compounds are tested for their antibacterial activity against gram positive and gram negative bacterial to establish the structure activity relationship. We are very thankful to UGC for financial support and Principal, Y.C.Institute of Science Satara (India) for providing Laboratory facilities.