Deficiencies in Health Care Worked performance in developing countries are due to a variety of causes. These include lack of health resources, low skill and undefined work processes. Regardless of the cause of poor Health Care Worker performance, the traditional solution has been to provide training. Consequently, many health training programs are conducted in the region. These include the training activities within Essential Medicines supply programs. The training programs employ variety of training approaches and methods. Developed on developed country models, the methods are often program depended, therefore making transferability of skills difficult. Interestingly, there is growing evidence that these resource-intensive training programs are not always effective. The evidence for the training effectiveness appears weak or lacking. As a result, demand is ever growing for other interventions that might help improve Health Care Workers’ performance. In this book, it is argued that the scaling up training programs aiming to improve medicines access is likely to waste resources with minimal improvements in health of the population.