The tetravalent metal complexes of amino acid derivative containing the M-O and M-N linkage display significant and versatile biological activity. The studies are likely to be a meaningful addition in the area of work now being pursued on the reactivity of metal alkoxides. The work described in this book broadly concerns with the synthesis, characterization of several tetravalent metal complexes of amino acid substituted ligands. The structures of the synthesized compounds were confirmed by elemental analysis, IR and 1H-NMR spectra. The present research work is divided into four chapters and all four chapters end with the references.The book is contained much useful spectral data, analytical detail and solubility behavior in the form of tables. This book not only fulfils the requirements of the new synthesis but also helpful for the researchers. In future we can do biological activities such as anti-tumor, anti-ulcer, anti-carcinogenesis, anti-inflammatory, herbicidal, insecticidal and further antimicrobial activities of these silicon, tin- and organotin(IV) complexes. In case of Titanium complexes we can do the, antimicrobial studies and catalytic property.