Activities of microorganisms are very important to almost every sector of concern to mankind. The applications of microorganisms to agriculture, forestry, food, industry, medicine, and environment. The scope and significance of microbiology has enlarged manifold, particularly when importance of environment was realized globally and the word environment was used in a much wider sense in terms of totality to include almost everything, every bit of nature. This subject concern with various field of science.This esteem also much involve medical Sciences because Antibiotic and other chemotherapeutic agents production by a range of microbes is well-known. Applications of microbes in industry are well known. Various microorganisms are used for commercial production of alcohols, acids, fermented foods, vitamins, medicines, enzymes etc. One recent development in industrial microbiology has been the production of immobilized enzymes and cells for production of these chemicals at enhanced rates with simultaneous recovery of the enzymes involved in such processes. New strains of microbes have also been developed through recombinant DNA technology for overproduction of metabolites.