A number of people are choosing to become entrepreneurs currently, starting their own business that enables them to lead meaningful careers. Entrepreneurship is now the driving force behind the economic development of every country. One of the major factors of economic growth is the level of entrepreneurial activity in that particular country. Entrepreneurs in MSEs as part of business community contribute to the country''s economic welfare. They produce substantial portion of our total goods and services. Thus, their economic contribution is comparable to that of big business. This paper attempted to examine the challenges and opportunities on the developmental issues of entrepreneurship in MSEs found in Adama Town.