The issue confronting the education system is how to transform the curriculum and teaching-learning process to meet the increasing pressure to use the new ICT to teach students in the 21st century. This study, therefore, explored the challenges facing ICT integration in the teaching and learning of mathematics and sciences in secondary schools in Vihiga District. The diffusion of innovations theory (Rogers, 1995) served as a theoretical framework. The study employed the descriptive research design. Questionnaires were administered among 15 secondary school head teachers, 110 teachers and 335 students of fifteen schools and interviews were done on 15 teachers using an interview schedule. Purposive sampling technique was used to sample 15 schools, which have been teaching computer studies. Data was analyzed using both descriptive and nferential statistics. The Statistical Package for Social Sciences version 15 (SPSS) was used. The study revealed that the extent of computer use among students, teachers in Vihiga District was minimal despite the positive attitude they had of computer use.