The species of Chlorophytum Ker-Gawl. are known as drug safed musali in different indigenous system of medicine, such as Ayurveda, Siddha, Unani and Tibbi. Ayurveda is an ancient Indian System of medicine, which generally deals with plants and plant extracts. This form of medicines involves treating various diseases by the active ingredients present in plant. Pharmacognosy is a highly applied branch of science, which involves the number of scientific disciplines for solving problems pertaining to the identity, purity, quality and preservation of the drugs of plant, animal and mineral origin. There are various methods designed to distinguish authentic crude drugs from their adulterants, based on there pharmacognosy. All these methods are useful to provide pharmacopoeial standards for the authentic drugs. Hence, in the present investigation detailed pharmacognostic study of six species of Chlorophytum have been carried out.