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The Ginsenosides: Yin and Yang in Angiogenesis

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Ginseng has been used as a general tonic for many years. Its pharmacological actions are attributed to a group of saponin glycosides – ginsenosides. Different ginsenosides was reported to exert counteracting actions on angiogenesis - the formation of new blood vessels. Recently, we demonstrated the Yin – Yang action on angiomodulation would be attributed to different group of ginsenosides. In this study, the results showed that Rg1 is a potent angiogenic compound; it induced proliferation and tube formation of endothelial cells, microvascular sprouting in the rat aortic ring model, neovascularization in the Matrigel plug model and modulating expression of genes related to cytoskeletal dynamics, cell-cell adhesion and migration. Conversely, Rg3 could attenuate the VEGF- induced chemoinvasion and tube formation of endothelial cells, and the gelatinolytic activities of MMP-2 and -9. This book provides new findings on the diversity of pharmacological actions of ginseng, and hence Chinese herbs. Furthermore, at least, ginsenosides Rg1 and Rg3 would be the potential components in ginseng that can be developed for the angiotherapy.

Product Specifications
SKU :COC48634
AuthorPatrick YUE and Ricky Wong
LanguageEnglish
BindingPaperback
Number of Pages180
Publishing Year2010-05-21T00:00:00.000
ISBN978-3838310718
Edition1 st
Book TypeBiology, life sciences
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-04-08 00:00:00