Farmers use pesticides as a major weapon to suppress various pest attacks, the use of which has increased in recent years due to increase in commercial farming. This has resulted in its indiscriminate use giving rise to several problems. Farmers have little or no knowledge of pesticides and their uses, as a result of which, general precautionary measures are also lacking. Since 2001, Nepal has banned all the Persistent Organic Pollutants pesticides. However, due to transboundary movement and illegal import, some of the banned pesticides are still found in local markets. But, as data is not always available, it is difficult to depict the trend. The enforcement of pesticide regulations is poor. Government confronts numerous constraints in terms of lack of qualified and trained personnel as well as the technical capacities in pesticide management which need to be substantially strengthened for the Government to be able to undertake its mandate to effectively implement the regulations relating to the production, importation, distribution and safe use of pesticides.