This work aspired for comprehending the longstanding crisis in the Middle East, mainly between Israelis and Palestinians. And also, it examined different peace accords and actors towards ensuring durable Peace in the Region. The most astonishing issue in the Israeli- Palestinian Conflict is the conflict stayed age- old, yet immature for resolution. It has been learned that overlapping claims and uncompromising demands have dragged the conflict almost for a century. Peace pacts, for the most part from Camp David I to Annapolis and other recent initiatives could not yield for lasting peace. Accordingly, hitherto peace processes have remained futile to warrant sustainable peace between and among parties in the conflict. The underlying causes of Israeli-Palestinian conflict, among others, include: Israeli- Settlements, Palestinian Refugees, quest for Jerusalem, Israeli-security demands and establishment of viable Palestine state. Consequently, this work gives an insight on perpetual crisis, cause and consequence of crisis; abortive peace accords, and stumbling block to guarantee peace in the Region and prospects.