The Olfactory Mucosa to Model Neurodevelopment in Psychiatric Illness

 

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  • Product Description
 

The ability to examine the dynamic process of neuronal birth, differentiation and death in neuroepithelium from individuals with psychosis could provide a powerful tool for understanding neurobiological underpinnings of schizophrenia and bipolar disorder. One neurodevelopmental model system, the olfactory epithelium, is a neuroepithelium analogous to that of the neural tube from which the brain develops in the embryo, is instructive in that regard. This tissue is a well-established model for molecular factors and genes that regulate neurogenesis. It is informative because it undergoes continual regeneration, and many of the elements of neuronal cell lineage, migration and survival are regulated by the same growth factors that act on the developing brain. Through an understanding of the basic biology of the developmental processes operating in the olfactory epithelium, this work demonstrates its utility to directly assess factors affecting neurodevelopment and the dysfunction of specific metabolic pathways at both the cellular and molecular level in psychiatric illness. The olfactory neuroepithelium is a useful model for investigating molecular and cellular aspects of neurogenesis.

Product Specifications
SKU :COC87282
AuthorRichard McCurdy
LanguageEnglish
BindingPaperback
Number of Pages276
Publishing Year2013-07-18T00:00:00.000
ISBN9783659398223
Edition1 st
Book TypeBiology, life sciences
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00
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