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The role of Autocoids and TRPV1 in mediation of Neurogenic inflammation

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

In this study we have investigated the sensitising effect that Prostaglandin E2 (PGE2) has on the action of bradykinin (BK) in both depolarising the resting membrane potential and in action potential generation and propagation in the isolated, desheathed vagus nerve using an extra cellular grease gap recording technique. Prostaglandin E2 sensitisation of the bradykinin induced depolarisation is mimicked by both activation of the protein kinase A and protein kinase C signalling pathways by a process that is completely blocked by the TRPV1 antagonist ruthenium red and staurosporin. This suggests a pivotal role for the vanilloid capsaicin sensitive receptor TRPV1 channel in the prostaglandin E2 and bradykinin induced response.

Product Specifications
SKU :COC95059
AuthorCharles Mugera
LanguageEnglish
BindingPaperback
Number of Pages56
Publishing Year2011-03-31T00:00:00.000
ISBN978-3844326505
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-14 00:00:00
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