The use of information and communications technology (ICT) in teaching-learning process is a relatively new phenomenon and it has been the educational researchers' focus of attention for more than two decades. The effective integration of technology into classroom practices poses a challenge to teachers and administrators. This research focuses on determining factors influencing use of ICT to make teaching-learning effective in higher institutions of learning in Uganda and identify the innovations that ICT has brought in teaching-learning process in higher institutions of learning in Uganda. A survey design was employed and in order to empirically investigate the role of ICT to make teaching-learning effective in higher institutions of learning in Uganda. 78% of a sample of 90 teaching staff and 41% of a sample of 75 administrators participated in the study. Chi square test and weighted average using SPSS software were used to analyse and interpret the data. The findings of the study revealed that teaching staff and administrators had a strong desire to integrate ICT into teaching-learning processes which are influenced by many factors.