ABSTRACT Recent spirituality research has sought to develop spirituality measures that empirically substantiate spirituality as a unique construct independent of established personality constructs. One such measure is Sanctification, a psychological process through which people perceive aspects of life to possess spiritual character and significance. The results indicated that the Sanctification of Work was a significant predictor of Job Satisfaction, Turnover Intention, and Organizational Commitment after controlling for Spirituality, Religiosity, Personality, Psychological Safety, and Demographic variables. The findings of the study identified that the Sanctification of Work predicted the largest amount of variance in Job Satisfaction and Organizational Commitment after controlling for the other predictors. The results supported the validity of the Sanctification of Work as an independent construct that assesses spirituality’s relationship to work-related outcomes. The findings suggest that the Sanctification of Work can be a resource for clinicians and clients in assessing the role of spirituality in work-related issues, such as career decisions or coping skills.