Managing change is a crucial and highly essential activity of any institution. In this material the study of managing the change with the help of Business Process Reengineering (BPR) implementation and its contribution to service delivery was conducted in 2009 by considering Mekele University, one of the higher education institutions in Ethiopia. The objectives of the study were to assess how change implemented in the University was managed and what were its contributions to service delivery. In order to achieve these objectives, descriptive survey research method was employed. Analysis of data revealed that the university has made significant efforts in implementing BPR and brought about remarkable results in the areas of student services. On the other hand, the university faced several challenges in the course of implementing BPR. The major challenges were the ICT infrastructure that was to capacitate the change remained a plan and employees were not motivated to implement the change. This work is important for professionals in the management sciences and for anyone who has interest in efficient and effective work environment in order to achieve organizational objectives.