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The Study of Hypertension:Antagonism of alpha 1D receptor


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

The development of new therapies to treat hypertension effectively is currently an intensive area of research. To achieve this objective quantitative structure activity relationship (QSAR) study was carried out on a reported series of phthalazine derivatives as alpha-1d antagonist, as it provides the rationale for the changes in the pharmacophore to have more potent and less toxic analogue. In this article, we report 2D and 3D QSAR studies for the set of 20, alpha-1d antagonist. A simple and convenient procedure has been developed for the synthesis of Novel 1 phthalazinone and 1, 4phthalazinedione derivatives using Schotten–Baumann reaction and Gabriel Michael reaction respectively. All compounds have been characterized by IR, NMR,and MASS spectroscopy.

Product Specifications
SKU :COC85194
AuthorVijay Rakholiya,Rohan Bamane and Santosh Gandhi
Number of Pages264
Publishing Year2013-09-29T00:00:00.000
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00