Theory-based investigations of the potassium ion channel family

Theory-based investigations of the potassium ion channel family


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

Potassium (K+) channels are tetrameric membrane proteins that play a critical role in diverse life-sustaining processes, e.g., the action potential. Their clinical significance is underscored by the observation that they are likely the founding members of the voltage-gated ion channel superfamily that includes sodium and calcium channels. The research aimed to address the gaps in our current understanding of K+ channel biology. The themes were as follows: classification of genome-complement of K+ channels; analysis of intrasubunit heterodomain co-evolution; sequence determinants of subfamily-specific channel phenotypes; and finally, structure-function-evolution relationships. The highlight was the detection of deep co-evolution between the permeation pathway of K+ channels and the corresponding channel regulatory domain. Reconstruction of the ancestral sequence of each subfamily yielded insights into the mutations that formed the biochemical basis for the range of functional differentiation present in the K+ channel protein family, notably two-pore, pacemaker and CNG channels. The work will be of interest to biophysicists, channelologists, bioinformatikers, and neuroscientists.

Product Specifications
SKU :COC87083
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08
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