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Thermal,Infrared and Solubility Study Of Repaglinide Solid Dispersion

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Solid dispersion techniques have been widely used as an effective method for enhancing the dissolution rate and bioavailability of poorly water soluble drugs. Current study was conducted to reveal the possibility of preparing repaglinide solid dispersions with improved aqueous solubility and dissolution rate, which will solve the difficulties in the development of pharmaceutical dosage forms of poorly water soluble drugs due to their limited water solubility, slow dissolution rate and low bioavailability. Repaglinide solid dispersion was prepared considering different variable factors: solvent variation (methanol, ethanol), polymer variation (HPMC, HPC, poloxomer, povidone K 12, povidone K 30), diluent variation (avicel, microcellac, aerosil, cross carmellose sodium, povidone VA 64, kollidon CL, talc), Drug load variation, effect of PEG 6000 content and drug release profile for different formulations was studied. Infrared spectroscopy and Thermal analysis by differential scanning calorimeter were studied. The results showed that the incorporation of different polymers transforms crystalline repaglinide into amorphous state, thus increasing its solubility and dissolution rate.

Product Specifications
SKU :COC31034
AuthorTahiatul Shams and Muhammad Shahdaat Bin Sayeed
LanguageEnglish
BindingPaperback
Number of Pages180
Publishing Year6/22/2012
ISBN978-3659166518
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00