Wound healing is a complex and dynamic process of restoring cellular structures and tissue layers. The study was conducted to compare the effectiveness of cyanoacrylate tissue adhesive with conventional suture in closing laparoscopic abdominal incision. They were randomly assigned to receive either tissue adhesive or suture. Main outcome measures were time taken for skin closure and post operative outcome. Both groups were comparable with respect to age, parity, education level, type of occupation and number of holes. In the study, there was a significant difference in time taken for skin closure where tissue adhesive was much more faster compared to suture. The use of tissue adhesive is easy and safe with complications comparable to suture and results in equally good cosmesis. Therefore tissue adhesive is a suitable alternative to suture in small wounds and low tension areas.