The study is a result of the valuable contribution of several individuals.I convey my profound gratitude to my Guide Prof. J.S Bapna, IIHMR, Prof. Ranjit Roy Chaudhury, Delhi Society for Promotion of Rational Use of Drugs (DSPRUD) who guided me all through the project period. I am also grateful to Dr. Uma Tekur,MAMC, Dr. Sangeeta Sharma, DSPRUD & Dr. Naresh Khanna,UCMS, Delhi for their timely guidance and consistent support. I am also thankful to all the three Medical Superintendents of LNJP, DDU & LBS Hospital for their wholehearted support.A word of appreciation also goes to staff of above three hospitals & DSPRUD for their cordial support. Last but not the least I would like to thank my parents (Shri Chakrapani Bhoi and Smt. Prafulla Bhoi) a my family members(Prakash Ch. Bhoi, Subash Ch. Bhoi,Bikas Ch. Bhoi, Kalpana Bhoi,Bhavani Saha) and friends who had been a constant source of inspiration for me and supported me throughout the study period. "This Book is dedicated to my Parents (Shri Chakrapani Bhoi and Smt. Prafulla Bhoi), my family members, my loving wife, Purnima amd my beloved daughter, Saanvi".