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Tocotrienol reverses nicotine-induced embryonic impairment in mice


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  • Product Description

This study evaluated the effects of nicotine and supplementation of tocotrienol (TCT) concurrently with nicotine on in vitro and in vivo embryonic development in mice (Mus musculus). In vitro effects of various doses and duration of nicotine treatment on pre-implantation embryos are dose- and treatment duration-dependant with increased lipid peroxidation (LP). TCT supplementation concurrently with nicotine prevents the deterioration of pre-implantation embryo quality through lowering LP activity. TCT supplementation also sustains the physiological sequence of blastocyst implantation, foetal growth, pregnancy outcome and survival of the neonates. It is postulated that TCT, an antioxidant could be used to minimize nicotine-induced oxidative stress-related deterioration of pre- and post-implantation embryo development, intrauterine foetal growth, pregnancy outcome and survival of the neonates.

Product Specifications
SKU :COC53531
AuthorYuhaniza Shafinie Kamsani,Mohd. Hamim Rajikin and AMAR CHATTERJEE
Number of Pages228
Publishing Year2014-07-16T00:00:00.000
Edition1 st
Book TypePre-clinical medicine: basic sciences
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-06-08 00:00:00
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