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TOR and GSK3 in the ciliate Paramecium tetraurelia


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  • Product Description

Target of rapamycin (TOR) is a serine threonine kinase that regulates cellular processes in response to the stresses and nutrients in the environment. We investigated TOR signaling pathway in the ciliate Paramecium tetraurelia (P. tetraurelia). Using BLAST (Basic Local Alignment Search Tool) we identified orthologs of the mammalian TOR, LST8, Akt, Rheb, Rag A/B, Rag C/D, SNAT2, Tap42, S6K, PKA and GSK3 in the P. tetraurelia. With RNA interference technique we established that depletion of these orthologs reduced cellular proliferation and arrested cells between G1 and S stages of the cell cycle. Furthermore, GSK3 depletion produced round looking cells with short, sparse cilia, and GSK3 was localized to the pellicle and cilia of P. tetraurelia. In addition to these investigations, we determined that inhibition of PKA with H89 prevented re-growth of cilia in de-ciliated cells. Our results possibly suggest that GSK3 and PKA work together in the regulation of ciliary length and /or assembly in P. tetraurelia. We also hypothesize that these regulations are TOR dependent.

Product Specifications
SKU :COC36498
AuthorTatyana Svinkina
Number of Pages340
Publishing Year5/30/2012
Edition1 st
Book TypeBiology, life sciences
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00