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Total Syntheses of Sansalvamide A, Cherimolapeptide C, E, & Analogues


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

Cherimolacyclopeptides are a class of cytotoxic cyclic peptides which exhibited significant activities against the human nasopharyngeal carcinoma cell culture system. The synthesis and study of cyclic peptide analogues presents a powerful move in the design and discovery of novel peptide drugs. Thus, the solid-phase syntheses of cherimolacyclopeptide E, cherimolacyclopeptide C, sansalvamide A, and the alanine-substituted analogues of cherimolacyclopeptide E were carried out in the present study. The synthetic cyclic peptides were then subjected to KB and MDA-MB-231 cell lines to examine the effect of side chain on the anticancer potential. The results indicated a significant enhancement in the activity of the analogues as compared to the parent peptide. The present study thus provides a new insight into peptide analogues and is especially useful for the scientific community involved in Solid-Phase Peptide Synthesis and anticancer activities or any one else who may be interested in alanine-scanning analogues.

Product Specifications
SKU :COC87561
AuthorTania Rizvi,Liaqat Ali and Farzana Shaheen
Number of Pages72
Publishing Year2013-02-04T00:00:00.000
Edition1 st
Book TypeChemistry
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00