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Total synthesis of (+)- Crocacin C, (-) – Basiliskamide A & B


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

This monograph describes introduction of Prins cyclisation, previous approaches to the versatile intermediate 1,3 diols and its application in the synthesis of polyketide natural products. Scope of the prins cyclisation in the synthesis of multisubstituted tetrahydropyrans from aldehydes and homo allylic alcohols, is expanded. A new approach for the stereoselective synthesis of polyketide precursors containing 1,3-diol units, flanked by divergent alkyl branches with different functional groups. Using this 1,3 diol strategy synthesized biologically active molecule Crocacin C (antifungal and highly cytotoxic metabolite), Basiliskamide A & B (showed the antifungal activity against Candida albicans and Aspergillus fumigates). This monograph is unique with dealing with synthetic protocols for above natural products utilizing Prins cyclisation and 1,3 diol strategy including full experimental procedures, analytical data, complete references section and most useful for synthetic organic chemists.

Product Specifications
SKU :COC40496
AuthorPurushothama Rao Ponugoti and J. S. Yadav Yadav
Number of Pages164
Publishing Year3/20/2012
Edition1 st
Book TypeOrganic chemistry
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-02-08 00:00:00