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Toxicity Versus Proximity


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  • Product Description

This approach was made by Dhir et al. based on X-ray Crystallography in terms of Toxicity versus Proximity on the basis of Ligand preparation and characterization by Nuclear Magnetic Spectroscopy, Infra red spectroscopy, Magnetic Susceptibility & CHN(Mass Analyzer) Techniques. DETP & DPTP have been found to be similar potential toxic as they have been used in fungicides and other antibacterial products. Approach has been made on the basis of Biomimetics. The study reveals that Cu complexes are much more potentially toxic than lead compounds because in lead compounds ligands may occupy all the centres or corners of the Pb(I/II)metal ions and very less void is left to interact physiochemically with various proteins/ amino acids or DNA of living cell to disrupt their cycle to become potential toxic and carcinogenic in nature. Thus Pb(I/II)metal ions are very toxic with less hydrophobic group while Cu(II) complexes are very toxic with big/steric ligands as compared to small one. This fact is strengthened on the basis of X-ray Crystal structure of one of the Copper (II) complexes.

Product Specifications
SKU :COC95091
AuthorVaneet Dhir and Pooja Dhand
Number of Pages64
Publishing Year2011-11-23T00:00:00.000
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-14 00:00:00