As on oral administration, Raloxifene Hydrochloride undergoes extensive first pass metabolism resulting in poor bioavailability. The Objective of the present study was to prepare a matrix patch of Raloxifene Hydrochloride to increase its bioavailability. The main aim of the work is to provide a safe, simple and alternative route of administration for the prevention of osteoporosis in post-menopausal women. This book gives insights into the innovative world of non invasive transdermal drug delivery. This compilation of work explains the preformualtion, formulation considerations, methodologies and evaluation parameters of developed system of transdermal patch. The book will serve as a guideline for the researchers in field of transdermal drug delivery.