Transdermal Patches Of An Antihypertensive Drug


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  • Product Description

The main focus of this research work was to develop a matrix type transdermal patch containing Propranolol hydrochloride and combination of two hydrophobic Polymers Eudragit L-100 and Eudragit S-100 by Solvent Evaporation technique.Combination of two Plasticizers Glycerine and Dibutyl phthalate were used and their effect on drug release was studied by changing their concentration in each batch.Methanol and Dichloromethane solvent system was used in which methanol acts as a penetration enhancer.Since oral bioavaibility of Propranolol Hydrochloride is poor due to high first pass metabolism transdermal patch is formed with the objective to get sustained release drug action with good bioavaibility. It can be concluded that the attempt of formulation and evaluation of the propranolol hydrochloride patches was found to be successful in the release of drug for an extended period of time. Further detailed investigations and elaborate in-vivo studies need to be carried out and an in-vitro in-vivo correlation need to established to guarantee the efficiency and bioavaibility of the formulation.

Product Specifications
SKU :COC85248
AuthorShitalkumar Patil,Sandip Kardile and Sachinkumar Patil
Number of Pages72
Publishing Year2013-12-25T00:00:00.000
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00
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