Nowdays,nurse managers need to utilize behaviors of transformational leadership which focus on staff nurses’ job satisfaction in healthcare environment. This descriptive correctional study was conducted to determine the levels of nurse managers’ transformational leadership, the levels of staff nurse job satisfaction, and to identify the relationship between transformational leadership and job satisfaction. This study introduce the management at the Second Teaching Hospital of Harbin Medical University in China. This study is important for nursing administrators to provide training program for nurse managers to improve their knowledge and skills of transformational leadership and develop effective strategies to improve the level of staff nurses’ job satisfaction. By raising the level of staff nurses’ job satisfaction at their work, the quality of work life may be elevated and the rates of turnover and shortage of nursing personnel may be reduced.