Although highly active antiretroviral therapy (HAART) reduces mortality in the developed world, it remains undocumented in resource-poor settings.The country specific data on the impact of the ART in reducing the HIV relating mortality and the survival data is unavailable. The effectiveness of HAART could vary from region to region because of the difference in background disease burden (such as tuberculosis or intestinal parasites), viral subtypes, and possible genetic differences in drug metabolism. However, such arguments are based on little data from the resource-limited settings. The objective of the study is to assess the treatment outcomes among the clients’ cohort in Antiretroviral Therapy in Kathmandu Valley The study aims to generate evidence on the outcomes of ART which can contribute to better program monitoring and management in developing country like Nepal. The study results are expected to serve as reference for the policy makers and Public Health professionals in tracing the direction of the major care and support component of HIV and AIDS program and evaluation of the ART program in resource poor settings.