The purpose of this book is to describe about the Tumor Necrosis Factor Alpha (TNF). The book describes about the history, structure and the pathology of TNF. Its in a format that is suitable for undergraduate students, regardless of academic backgrounds or fields of study: liberal arts, biology, nursing, pharmacy, or other allied health professions.The most significant feature of this book is its clear, up-to-date, accurate explanations of mechanisms, rather than the more description of facts and events. The pathology of the diseases that involve Tumor necrosis factor is also explained by self explaining diagrams. We have attempted to explain, integrate, synthesize information rather than simply to describe. : Ashok Bhambu & Smriti Rai.