Diagnosis of human schistosomiasis is very central to make a decision on individual case management, at all stages of control programs and for comparing control programs. The conventional ways of demonstrating parasite eggs in feces and urine for diagnosis of infection by schistosomes have drawbacks in sensitivity, especially in case of light infection. These drawbacks attracted researchers'' attention for innovation of new approaches which are reliable, easy to perform. The occurrence and development of schistosomiasis is strongly depended on human immunity against schistosomes. Thus, analysis of schistosome antigens is useful for providing antigens for establishing a specific, sensitive diagnostic technique. The excretion of the schistosome circulating antigens in the urine of infected patients makes possibility for simple diagnosis of schistosomiasis.Therefore, this research work is an attempt to detect these circulating antigens in urine of schistosomiasis patients which could be a successful diagnostic tool, follow-up schistosomiasis treatment efficiency and vaccination in the future.