This study of user competence and information system success takes place in the medical laboratory industry. Information system use is a primary measure of information system success. Use is often measured by frequency or voluntariness of use. Multidimensional use represents a more evolved, business relevant form of information system use. Individual difference is an external variable affecting beliefs that can influence how well information systems are used. In this study, individual difference is measured in terms of competency indicators, gender, education level, current job title, years in profession, type of institution, and shift worked. Competency indicators are the independent variables of this study and the multidimensional use of information systems is the dependent variable. While support for the existence of a relationship between competency indicators and multidimensional use is inconclusive, significant differences in information system use were identified by job title and institution type. These findings have both academic and practical implications.