The proposed method was quite simple and do not require any pretreatment of drugs and tedious extraction procedure. The method has wider linear range. Hence,the data presented in the manuscript “Validated UV Spectrophotometric and RP-HPLC method development for the simultaneous estimation of Sitagliptin and Simvastatin in marketed Formulation” demonstrate that the proposed method is linear and offer advantages of reagent availability and stability, less time consumption.The statisticalanalysis proves that the methods are reproducible and selective for the estimation of Sitagliptin and Simvastatin in marketed tablet formulation. Thus it can be extended for routine analysis of Sitagliptin and Simvastatin in pharmaceutical industries, hospitals, and research laboratories. These all process is done for the betterment of medicine, so that no or less side effects occur.