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VDR mediated calcitriol signalling related to ?6?1- and ?6?4-Integrin


Marketed By :  VDM Verlag Dr. Müller   Sold By :  Kamal Books International  
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  • Product Description

Basal keratinocytes are attachment-dependent cells, interacting with their surface to neighbouring cells e.g. integrin mediated mechanisms. Their proliferation and differentiation is regulated by 1,25-dihydroxyvitaminD3, that also influences the mRNA expression of integrins especially, heterodimers between different integrin types. Integrin ?6 is able to form heterodimers in keratinocytes with either ?1 or ?4. Using real-time expriments, the influence of 1,25-dihydroxyvitaminD3 on integrin gene-expression in human HaCaTs was studied in vitro. Additionally we performed VDR promoter binding studies using ChIP assays. It was hypothized that calcitriol regulates the cellular concentration of integrins and shifts the equilibrium of ?6, ?1 and ?4 heterodimers. The ?6/?4 heterodimer is preferred in HaCat cells in the presence of calcitriol and ?6/?1 heterodimer suffers from the compound. Since ?6/?4 heterodimers are responsible for adhesion of basal keratinocytes to the underlying matrix in the human skin, we conclude an increased adhesion capacity of basal keratinocytes to the basal lamina in the presence of calcitriol.

Product Specifications
SKU :COC43635
AuthorEva Steidle
Number of Pages124
Publishing Year2010-10-06T00:00:00.000
Edition1 st
Book TypeGenetics (non-medical)
Country of ManufactureIndia
Product BrandVDM Verlag Dr. Müller
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-01-08 00:00:00
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