The centrality of finance for enhancing development and growth even in developing countries is well established. In the United States of America, venture capital industry has been in existence since the end of World War II. It has helped to create many of today’s global enterprises and a recent report confirms that companies supported by venture capital in their formative years outperformed those that were not on many parameters. Venture capital has emerged as an important intermediary in financial markets, providing capital to young promising firms that might have otherwise gone unfunded. Venture capital focuses on enterprises that can generate high-growth and become at least regional, if not global, players providing employment to a large number of workers. There is therefore the need to assess the contributions of venture capital trust fund (VCTF) to the economy of Ghana and thereby acknowledge its importance and how best to harness its benefits to the country’s economic development. The main objective of the study is to examine the role of venture capital financing in promoting and maintaining small and medium scale enterprises (SMEs) in Ghana.