Vitiligo is an age old problem. It is considered as a stigma even in our developed society. In this study homeopathic medicines showed promising results in the treatment of vitiligo cases. Among 200 patients attended at Ramakrishna Mission Charitable Dispensary, Belur Math outpatient department, 190 patients showed encouraging responses. Medicines used were calc. carb., lycopodium, lachesis, mezerium, nat. mur., sepia, ars.s.fl., with dilutions – 200/1000. Pre- and post-treatment biopsy confirmed regeneration of pigments with disappearance of the white spots after treatment when histological examinations were done. As the treatment procedure was simple, patient compliance was good. The outcome of this study creates hope for eradication of vitiligo as a whole in the community.