Despite the high risks associated with indiscriminate disposal of solid waste, some residents in the Cape Coast Metropolis continue to bury, burn and dump refuse anywhere in their homes and surroundings without considering the health effects of their action. The study seeks to explore residents? perception, attitude and disposal practices of solid waste disposal and its health impacts in the Cape Coast Metropolis. Data for the study was obtained from two hundred and eighty - four (284) respondents. Multi-stage sampling procedure was used to generate the sample for the study. The main tool employed in gathering the data was questionnaire. The theory of planned behaviour was used to explain residents? action. The result of the study revealed that most of the respondents (75.0%) disposed of their solid waste in nearby skips with quite a number of respondents disposing their solid waste on the street. Among the solid waste disposal practices, recycling was the preferred disposal method. Forty-six per cent of the respondents expressed the opinion that the onus lies on the Metropolitan Assembly to ensure clean environments.