After years of estrangements, the tragic event of September 11, 2001, once again prompted a ‘marriage of convenience’ between the two entangled partners, the United States and Pakistan, yet for the third time dubbed as the 'third time entente'. However, since 2008, after General Pervez Musharraf left the presidency of Pakistan, US-Pakistan relations have been in doldrums. A number of factors are held responsible viz., Taliban remnants gaining refuge in Pakistan, use of Afghanistan-Pakistan border areas as staging grounds for Taliban offensive against the US and the ISAF forces, Pakistan’s intelligence agencies alleged collusion with the extremist elements, and the unprecedented rise of extremism in Pakistan to such extensity that the very foundation of the country is in ruins. Many of these factors are in fact, attributable to the outcome resulting from the policies pursued by the US during the Musharraf presidency. This book thus, is an attempt to seek answer to the question, ‘what is wrong with US-Pakistan relations’ by reflecting back with a comprehensive analysis of the US-Pakistan relations during the regime of General Pervez Musharraf, the last military dictator of Pakistan.