In this book, we are present fiber optic sensors design, multiplexing and loop topology based network techniques by utilizing advanced white light interferometric knowledge to meet the requirement of large-scale structural monitoring. What we focus on are?(1) how to create an interferometer system for white light interferometric fiber optic sensors interrogating? (2) how to calibrate and predict the embedded fiber optic sensors performance? (3) how to build a fiber optic sensors array on a single fiber by low coherence multiplexing techniques? (4) how to configure a loop topology based fiber optic sensors local network by white light interferometer for large-scale smart materials and structures health monitoring?