The study was carried out to cephalometrically evaluate the morphology of cranial base, midface and dental characteristics in subjects with Down’s syndrome and to compare the same with that of normal. The growth of cranial base and maxilla was also evaluated. As the thorough knowledge of the craniofacial morphology and dental characteristics help the orthodontist in arriving at a more accurate diagnosis about orthodontic problems. The attempt of our study is to give an idea about the craniofacial morphology in individuals with Down’s syndrome, which will help us to understand the basic morphological characteristics of these individuals. This will lead us to reach a proper diagnosis and treatment planning.