For centuries, it was the men who worked to make money and women remained at home to raise the children and fulfilled the household duties. Since World War II, there have been dramatic changes in the family and the workforce, including an increase in the number of women working in the paid labor force and more dual career couples. Participation of women in the workforce unavoidably resulted in remarkable changes in the families. Increasing number of families in which both husband and wife work likely creates even more important conflicts between work and family. In such families employed women have higher combined pressures from work and family responsibilities that lead them to experience work-family conflict. Therefore, this study intends to investigate the relationship between work factors, family factors and individual factor, with work-family conflict among nurses in Shiraz-Iran. It is expected that this book will provide useful implications for policy and program makers and will help married female nurses to balance their work and family responsibilities.